Monoaminergic effects of high‐dose corticotropin in corticotropin‐responsive pediatric opsoclonus‐myoclonus
Identifieur interne : 004F54 ( Main/Exploration ); précédent : 004F53; suivant : 004F55Monoaminergic effects of high‐dose corticotropin in corticotropin‐responsive pediatric opsoclonus‐myoclonus
Auteurs : Michael R. Pranzatelli [États-Unis] ; Yung-Yu Huang [États-Unis] ; Elizabeth Tate [États-Unis] ; David S. Goldstein [États-Unis] ; Courtney S. Holmes [États-Unis] ; Edward M. Goldstein [États-Unis] ; Karen Ketner [États-Unis] ; Morris Kinast [États-Unis] ; Bernadette M. Lange [États-Unis] ; Alfred Sanz [États-Unis] ; Michael I. Shevell ; Richard E. Stanford [États-Unis] ; Ingrid P. Taff [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1998-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Enfant.
English descriptors
- KwdEn :
- 3,4-Dihydroxyphenylacetic Acid (cerebrospinal fluid), ACTH, Adenohypophyseal hormone, Adrenocorticotropic Hormone (administration & dosage), CSF 5‐HIAA, Catecholamine, Catecholamines (cerebrospinal fluid), Cerebrospinal fluid, Chemotherapy, Child, Child, Preschool, Corticotropin, Dihydroxyphenylalanine (cerebrospinal fluid), Female, HVA, High dose, Homovanillic Acid (cerebrospinal fluid), Humans, Hydroxyindoleacetic Acid (cerebrospinal fluid), Infant, Male, Myoclonus, Myoclonus (cerebrospinal fluid), Myoclonus (drug therapy), Neurotransmitter Agents (cerebrospinal fluid), OMS, Ocular Motility Disorders (cerebrospinal fluid), Ocular Motility Disorders (drug therapy), Opsoclonus, Paraneoplastic, Reference Values, Treatment.
- MESH :
- chemical , administration & dosage : Adrenocorticotropic Hormone.
- chemical , cerebrospinal fluid : 3,4-Dihydroxyphenylacetic Acid, Catecholamines, Dihydroxyphenylalanine, Homovanillic Acid, Hydroxyindoleacetic Acid, Neurotransmitter Agents.
- cerebrospinal fluid : Myoclonus, Ocular Motility Disorders.
- drug therapy : Myoclonus, Ocular Motility Disorders.
- Child, Preschool, Female, Humans, Infant, Male, Reference Values.
Abstract
Children with the opsoclonus‐myoclonus syndrome (OMS) usually respond to corticotropin (adrenocorticotrophic hormone, ACTH) treatment but the mechanism of benefit is unknown. We previously showed that both cerebrospinal fluid (CSF) homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA) concentrations are low in pediatric OMS. In this study, we measured levels of CSF Dopa, catecholamines, deaminated metabolites of catecholamines, as well as HVA and 5‐HIAA in eight patients before and during treatment with ACTH. All the children were ACTH‐responsive with 50‐70% improvement in multiple clinical features of OMS. ACTH treatment reduced the HVA concentration in every child by a mean of 21% (p < 0.001). Treatment with ACTH was associated with significant correlations between dopaminergic markers such as HVA, dihydroxyphenylacetic acid (DOPAC), and Dopa. There were no significant changes in the CSF concentrations of the noradrenergic markers norepinephrine (NE) and dihydroxyphenylglycol (DHPG), or the serotonergic marker 5‐HIAA. The only child with a marked inflammatory pattern in CSF, which was reversed by ACTH, was atypical for a large increase in NE and decrease in 5‐HIAA levels. The pattern of decreased HVA and unchanged DOPAC levels could reflect decreased extraneuronal uptake of catecholamines (which steroids inhibit) or decreased 0‐methylation of catecholamines in nonneuronal cells.
Url:
DOI: 10.1002/mds.870130323
Affiliations:
- États-Unis
- Arkansas, Californie, District de Columbia, Géorgie (États-Unis), Maryland, New Jersey, Oklahoma, État de New York
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001665
- to stream Istex, to step Curation: 001665
- to stream Istex, to step Checkpoint: 003689
- to stream PubMed, to step Corpus: 004415
- to stream PubMed, to step Curation: 004415
- to stream PubMed, to step Checkpoint: 004393
- to stream Ncbi, to step Merge: 004F68
- to stream Ncbi, to step Curation: 004F68
- to stream Ncbi, to step Checkpoint: 004F68
- to stream Main, to step Merge: 007E66
- to stream PascalFrancis, to step Corpus: 003021
- to stream PascalFrancis, to step Curation: 003803
- to stream PascalFrancis, to step Checkpoint: 002F77
- to stream Main, to step Merge: 008101
- to stream Main, to step Curation: 004F54
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Monoaminergic effects of high‐dose corticotropin in corticotropin‐responsive pediatric opsoclonus‐myoclonus</title>
<author><name sortKey="Pranzatelli, Michael R" sort="Pranzatelli, Michael R" uniqKey="Pranzatelli M" first="Michael R." last="Pranzatelli">Michael R. Pranzatelli</name>
</author>
<author><name sortKey="Huang, Yung U" sort="Huang, Yung U" uniqKey="Huang Y" first="Yung-Yu" last="Huang">Yung-Yu Huang</name>
</author>
<author><name sortKey="Tate, Elizabeth" sort="Tate, Elizabeth" uniqKey="Tate E" first="Elizabeth" last="Tate">Elizabeth Tate</name>
</author>
<author><name sortKey="Goldstein, David S" sort="Goldstein, David S" uniqKey="Goldstein D" first="David S." last="Goldstein">David S. Goldstein</name>
</author>
<author><name sortKey="Holmes, Courtney S" sort="Holmes, Courtney S" uniqKey="Holmes C" first="Courtney S." last="Holmes">Courtney S. Holmes</name>
</author>
<author><name sortKey="Goldstein, Edward M" sort="Goldstein, Edward M" uniqKey="Goldstein E" first="Edward M." last="Goldstein">Edward M. Goldstein</name>
</author>
<author><name sortKey="Ketner, Karen" sort="Ketner, Karen" uniqKey="Ketner K" first="Karen" last="Ketner">Karen Ketner</name>
</author>
<author><name sortKey="Kinast, Morris" sort="Kinast, Morris" uniqKey="Kinast M" first="Morris" last="Kinast">Morris Kinast</name>
</author>
<author><name sortKey="Lange, Bernadette M" sort="Lange, Bernadette M" uniqKey="Lange B" first="Bernadette M." last="Lange">Bernadette M. Lange</name>
</author>
<author><name sortKey="Sanz, Alfred" sort="Sanz, Alfred" uniqKey="Sanz A" first="Alfred" last="Sanz">Alfred Sanz</name>
</author>
<author><name sortKey="Shevell, Michael I" sort="Shevell, Michael I" uniqKey="Shevell M" first="Michael I." last="Shevell">Michael I. Shevell</name>
</author>
<author><name sortKey="Stanford, Richard E" sort="Stanford, Richard E" uniqKey="Stanford R" first="Richard E." last="Stanford">Richard E. Stanford</name>
</author>
<author><name sortKey="Taff, Ingrid P" sort="Taff, Ingrid P" uniqKey="Taff I" first="Ingrid P." last="Taff">Ingrid P. Taff</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F14D1F55132B7EAB82E8639682DFAC9E710628D7</idno>
<date when="1998" year="1998">1998</date>
<idno type="doi">10.1002/mds.870130323</idno>
<idno type="url">https://api.istex.fr/document/F14D1F55132B7EAB82E8639682DFAC9E710628D7/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001665</idno>
<idno type="wicri:Area/Istex/Curation">001665</idno>
<idno type="wicri:Area/Istex/Checkpoint">003689</idno>
<idno type="wicri:doubleKey">0885-3185:1998:Pranzatelli M:monoaminergic:effects:of</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:9613746</idno>
<idno type="wicri:Area/PubMed/Corpus">004415</idno>
<idno type="wicri:Area/PubMed/Curation">004415</idno>
<idno type="wicri:Area/PubMed/Checkpoint">004393</idno>
<idno type="wicri:Area/Ncbi/Merge">004F68</idno>
<idno type="wicri:Area/Ncbi/Curation">004F68</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004F68</idno>
<idno type="wicri:doubleKey">0885-3185:1998:Pranzatelli M:monoaminergic:effects:of</idno>
<idno type="wicri:Area/Main/Merge">007E66</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:98-0262030</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">003021</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003803</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002F77</idno>
<idno type="wicri:doubleKey">0885-3185:1998:Pranzatelli M:monoaminergic:effects:of</idno>
<idno type="wicri:Area/Main/Merge">008101</idno>
<idno type="wicri:Area/Main/Curation">004F54</idno>
<idno type="wicri:Area/Main/Exploration">004F54</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Monoaminergic effects of high‐dose corticotropin in corticotropin‐responsive pediatric opsoclonus‐myoclonus</title>
<author><name sortKey="Pranzatelli, Michael R" sort="Pranzatelli, Michael R" uniqKey="Pranzatelli M" first="Michael R." last="Pranzatelli">Michael R. Pranzatelli</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>National Pediatric Myoclonus Center, Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Huang, Yung U" sort="Huang, Yung U" uniqKey="Huang Y" first="Yung-Yu" last="Huang">Yung-Yu Huang</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Neuroscience, New York State Psychiatric Institute, and Department of Psychiatry, Columbia University, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tate, Elizabeth" sort="Tate, Elizabeth" uniqKey="Tate E" first="Elizabeth" last="Tate">Elizabeth Tate</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>National Pediatric Myoclonus Center, Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Goldstein, David S" sort="Goldstein, David S" uniqKey="Goldstein D" first="David S." last="Goldstein">David S. Goldstein</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Clinical Neuroscience Branch, NINDS, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Holmes, Courtney S" sort="Holmes, Courtney S" uniqKey="Holmes C" first="Courtney S." last="Holmes">Courtney S. Holmes</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Clinical Neuroscience Branch, NINDS, NIH, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Goldstein, Edward M" sort="Goldstein, Edward M" uniqKey="Goldstein E" first="Edward M." last="Goldstein">Edward M. Goldstein</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
<wicri:cityArea>Scottish Rite Children's Center, Atlanta</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ketner, Karen" sort="Ketner, Karen" uniqKey="Ketner K" first="Karen" last="Ketner">Karen Ketner</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Pediatrics, UCSF Stanford Medical Center, Palo Alto</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kinast, Morris" sort="Kinast, Morris" uniqKey="Kinast M" first="Morris" last="Kinast">Morris Kinast</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>National Pediatric Myoclonus Center, Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lange, Bernadette M" sort="Lange, Bernadette M" uniqKey="Lange B" first="Bernadette M." last="Lange">Bernadette M. Lange</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arkansas</region>
</placeName>
<wicri:cityArea>Division of Child Neurology, Arkansas Children's Hospital, Little Rock</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sanz, Alfred" sort="Sanz, Alfred" uniqKey="Sanz A" first="Alfred" last="Sanz">Alfred Sanz</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Department of Pediatrics, St. Joseph's Hospital, Paterson</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shevell, Michael I" sort="Shevell, Michael I" uniqKey="Shevell M" first="Michael I." last="Shevell">Michael I. Shevell</name>
<affiliation><wicri:noCountry code="subField">Quebec</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Stanford, Richard E" sort="Stanford, Richard E" uniqKey="Stanford R" first="Richard E." last="Stanford">Richard E. Stanford</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>National Pediatric Myoclonus Center, Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Taff, Ingrid P" sort="Taff, Ingrid P" uniqKey="Taff I" first="Ingrid P." last="Taff">Ingrid P. Taff</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Baptist Medical Center, Oklahoma City, OK</wicri:regionArea>
<placeName><region type="state">Oklahoma</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1998-05">1998-05</date>
<biblScope unit="vol">13</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="522">522</biblScope>
<biblScope unit="page" to="528">528</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">F14D1F55132B7EAB82E8639682DFAC9E710628D7</idno>
<idno type="DOI">10.1002/mds.870130323</idno>
<idno type="ArticleID">MDS870130323</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3,4-Dihydroxyphenylacetic Acid (cerebrospinal fluid)</term>
<term>ACTH</term>
<term>Adenohypophyseal hormone</term>
<term>Adrenocorticotropic Hormone (administration & dosage)</term>
<term>CSF 5‐HIAA</term>
<term>Catecholamine</term>
<term>Catecholamines (cerebrospinal fluid)</term>
<term>Cerebrospinal fluid</term>
<term>Chemotherapy</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Corticotropin</term>
<term>Dihydroxyphenylalanine (cerebrospinal fluid)</term>
<term>Female</term>
<term>HVA</term>
<term>High dose</term>
<term>Homovanillic Acid (cerebrospinal fluid)</term>
<term>Humans</term>
<term>Hydroxyindoleacetic Acid (cerebrospinal fluid)</term>
<term>Infant</term>
<term>Male</term>
<term>Myoclonus</term>
<term>Myoclonus (cerebrospinal fluid)</term>
<term>Myoclonus (drug therapy)</term>
<term>Neurotransmitter Agents (cerebrospinal fluid)</term>
<term>OMS</term>
<term>Ocular Motility Disorders (cerebrospinal fluid)</term>
<term>Ocular Motility Disorders (drug therapy)</term>
<term>Opsoclonus</term>
<term>Paraneoplastic</term>
<term>Reference Values</term>
<term>Treatment</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adrenocorticotropic Hormone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>3,4-Dihydroxyphenylacetic Acid</term>
<term>Catecholamines</term>
<term>Dihydroxyphenylalanine</term>
<term>Homovanillic Acid</term>
<term>Hydroxyindoleacetic Acid</term>
<term>Neurotransmitter Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Myoclonus</term>
<term>Ocular Motility Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Myoclonus</term>
<term>Ocular Motility Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Reference Values</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Catécholamine</term>
<term>Chimiothérapie</term>
<term>Corticotropine</term>
<term>Dose forte</term>
<term>Enfant</term>
<term>Hormone adénohypophysaire</term>
<term>Liquide céphalorachidien</term>
<term>Myoclonie</term>
<term>Opsoclonie</term>
<term>Traitement</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Children with the opsoclonus‐myoclonus syndrome (OMS) usually respond to corticotropin (adrenocorticotrophic hormone, ACTH) treatment but the mechanism of benefit is unknown. We previously showed that both cerebrospinal fluid (CSF) homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA) concentrations are low in pediatric OMS. In this study, we measured levels of CSF Dopa, catecholamines, deaminated metabolites of catecholamines, as well as HVA and 5‐HIAA in eight patients before and during treatment with ACTH. All the children were ACTH‐responsive with 50‐70% improvement in multiple clinical features of OMS. ACTH treatment reduced the HVA concentration in every child by a mean of 21% (p < 0.001). Treatment with ACTH was associated with significant correlations between dopaminergic markers such as HVA, dihydroxyphenylacetic acid (DOPAC), and Dopa. There were no significant changes in the CSF concentrations of the noradrenergic markers norepinephrine (NE) and dihydroxyphenylglycol (DHPG), or the serotonergic marker 5‐HIAA. The only child with a marked inflammatory pattern in CSF, which was reversed by ACTH, was atypical for a large increase in NE and decrease in 5‐HIAA levels. The pattern of decreased HVA and unchanged DOPAC levels could reflect decreased extraneuronal uptake of catecholamines (which steroids inhibit) or decreased 0‐methylation of catecholamines in nonneuronal cells.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Arkansas</li>
<li>Californie</li>
<li>District de Columbia</li>
<li>Géorgie (États-Unis)</li>
<li>Maryland</li>
<li>New Jersey</li>
<li>Oklahoma</li>
<li>État de New York</li>
</region>
</list>
<tree><noCountry><name sortKey="Shevell, Michael I" sort="Shevell, Michael I" uniqKey="Shevell M" first="Michael I." last="Shevell">Michael I. Shevell</name>
</noCountry>
<country name="États-Unis"><region name="District de Columbia"><name sortKey="Pranzatelli, Michael R" sort="Pranzatelli, Michael R" uniqKey="Pranzatelli M" first="Michael R." last="Pranzatelli">Michael R. Pranzatelli</name>
</region>
<name sortKey="Goldstein, David S" sort="Goldstein, David S" uniqKey="Goldstein D" first="David S." last="Goldstein">David S. Goldstein</name>
<name sortKey="Goldstein, Edward M" sort="Goldstein, Edward M" uniqKey="Goldstein E" first="Edward M." last="Goldstein">Edward M. Goldstein</name>
<name sortKey="Holmes, Courtney S" sort="Holmes, Courtney S" uniqKey="Holmes C" first="Courtney S." last="Holmes">Courtney S. Holmes</name>
<name sortKey="Huang, Yung U" sort="Huang, Yung U" uniqKey="Huang Y" first="Yung-Yu" last="Huang">Yung-Yu Huang</name>
<name sortKey="Ketner, Karen" sort="Ketner, Karen" uniqKey="Ketner K" first="Karen" last="Ketner">Karen Ketner</name>
<name sortKey="Kinast, Morris" sort="Kinast, Morris" uniqKey="Kinast M" first="Morris" last="Kinast">Morris Kinast</name>
<name sortKey="Lange, Bernadette M" sort="Lange, Bernadette M" uniqKey="Lange B" first="Bernadette M." last="Lange">Bernadette M. Lange</name>
<name sortKey="Sanz, Alfred" sort="Sanz, Alfred" uniqKey="Sanz A" first="Alfred" last="Sanz">Alfred Sanz</name>
<name sortKey="Stanford, Richard E" sort="Stanford, Richard E" uniqKey="Stanford R" first="Richard E." last="Stanford">Richard E. Stanford</name>
<name sortKey="Taff, Ingrid P" sort="Taff, Ingrid P" uniqKey="Taff I" first="Ingrid P." last="Taff">Ingrid P. Taff</name>
<name sortKey="Tate, Elizabeth" sort="Tate, Elizabeth" uniqKey="Tate E" first="Elizabeth" last="Tate">Elizabeth Tate</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004F54 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004F54 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:F14D1F55132B7EAB82E8639682DFAC9E710628D7 |texte= Monoaminergic effects of high‐dose corticotropin in corticotropin‐responsive pediatric opsoclonus‐myoclonus }}
This area was generated with Dilib version V0.6.23. |